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. 2017 Oct 5;2(19):e95367. doi: 10.1172/jci.insight.95367

Figure 6. VZV-specific mc IgGs as determined by the MIAA assay.

Figure 6

(A) Results of the multiplex infectious-antigen array (MIAA) assay for the 4 patients found to have a varicella zoster virus–specific (VZV-specific) monoclonal (mc) IgG. For each patient, the results obtained for VZV glycoprotein E (gE) and ORF-26 with the patient’s serum (S) and purified mc IgG (mc) are shown. (B) Detail of results obtained for patient P109: P109 serum contained IgG that recognized CMV, EBV nuclear antigen-1 (EBNA-1), herpes simplex virus-1 (HSV-1), VZV gE, and VZV ORF-26, whereas purified mc IgG recognized only VZV gE. The fluorescence values shown for each pathogen, Ag, or lysate were obtained after subtraction of the threshold of specific positivity of the pathogen, Ag, or lysate (1,400 for VZV). Dots may be superimposed; black horizontal bars represent the means of results obtained for a pathogen, Ag, or lysate. Experiments were performed at least twice.