Fig. 6.

Insulin-induced glucose flux is reduced by BPMR2 mutation in isolated endothelial cells. (a) The rate of utilization of glucose from supernatant media was reduced by BMPR2 mutation with Mutation1 having a more profound effect than Mutation2. (b) There was increased intracellular glucose analogue in PMVECs under insulin stimulation, an effect significantly reduced by the presence of BMRP2 mutation. *P < 0.05 compared with cells without BMPR2 mutation. Six technical replicates used for each experiment.