Table 1.

Common side effects of medications that target the prostacyclin pathway.

Medications	Route	Related to the administration routes	Related to the pharmacological action
Epoprostenol	Continuous intravenous infusion	Catheter-related infections, sepsis, thromboembolic event, bleeding, drug-delivery system malfunction	Jaw pain, diarrhea, flushing, headaches, nausea, vomiting
Iloprost	Inhaled	Cough, throat irritation	Flushing, jaw pain, headaches, hypotension, body aches, nausea, diarrhea, dizziness
Treprostinil	Oral	Pill shell may not be absorbed and may be visibly excreted in the feces	Headaches, flushing, nausea, diarrhea, jaw pain, vomiting, extremity pain
	Continuous subcutaneous infusion	Infusion site pain, site reaction, and site abscess	Diarrhea, jaw pain, flushing, nausea, rash, dizziness, vomiting, headaches, flushing
	Continuous intravenous infusion	Catheter-related infections, thromboembolic event, drug-delivery system malfunction	Extremity pain, headaches, diarrhea, jaw pain, nausea, fatigue, loose stools, vomiting, dizziness, dyspnea, flushing, palpitations, peripheral edema
	Inhaled	Cough, throat irritation,	Headaches, nausea, flushing, diarrhea, dizziness
		Pharyngolaryngeal pain	Dizziness
Selexipag	Oral	N/A	Headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, flushing

N/A, not applicable.