Figure 3.
The inhibitory effect of NaHS on the contractile response in basilar arteries (BA) induced by 40 mM KCl. We treated 9-week-old male SHR and WKY rats with NaHS (56 μmol/kg−1·day−1, i.p.) or the same volume of normal saline and continued every day. At 9 weeks after NaHS injection, BA were isolated and their contractile response were determined as described in “Materials and methods”. Contraction of BA in response to KCl was greater in SHR than in WKY rats (* P<0.05). Long-term NaHS treatment suppressed vascular contraction of cerebral arteries from SHR in response to KCl (# P<0.05 vs. SHR). All data-points are from 7 BA. Results are means ±SEM of 4–6 experiments.