Figure 5.
Effect of long-term NaHS treatment on the production of pro-inflammatory and anti-inflammatory cytokines in serum of SHR. We treated 9-week-old male SHR and WKY rats with NaHS (56 μmol/kg−1·day−1, i.p.) or the same volume of normal saline and continued every day. At 9 weeks after NaHS injection, serum level of IL-2 (A), IL-6 (B) and IL-10 (C) were determined as described in “Materials and methods”. Data represented as total amount of cytokine produced in pg/ml in peripheral blood; the results shown are the mean ±SEM; * P<0.05 and ** P<0.01, compared with the WKY rats; ## P<0.01, compared with SHR (n=15 animals in each group).