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. 2018 Feb 27;7:e31543. doi: 10.7554/eLife.31543

Figure 3. Decreased bursting of CA1 pyramidal cells in Dp(16)1Yey mice during post-exploratory rest.

Figure 3.

During post-exploratory quiescent periods the peak firing rate (A) and mean firing rate (B) were not significantly different between the WT and Dp(16)1Yey groups. (C) The complex spiking index was significantly decreased in Dp(16)1Yey CA1 pyramidal cells. (D) The ISI distribution shows two populations of events in CA1 pyramidal cells from WT mice. The peak of events with an ISI between 2 and 15 ms correspond to spikes included in complex bursts. The second large population of events with higher ISI represents single isolated spikes. In the Dp(16)1Yey the peak of short ISI events was smaller than in WT, whereas the population of isolated single spikes tended to be larger. (E) The inter-spike interval (ISI) mode, defined as the most probable inter-spike interval for each recorded neuron, was significantly longer in the Dp(16)1Yey group than in their WT littermates. Statistical significance was assessed using Mann-Whitney U-test with significance set at (***) p<0.001.

Figure 3—source data 1. Pyramidal cells characteristics during awake-rest - full data set.
elife-31543-fig3-data1.xlsx (87KB, xlsx)
DOI: 10.7554/eLife.31543.008