(A) Compared to the standard detection threshold (commonly placed at 3 SD), using a more permissive threshold (2 SD) led to a larger number of ripples detected in both WT and Dp16 mice. The frequency of occurrence of ripple events was significantly higher in Dp16 than their WT littermates. On the contrary, using a more restrictive threshold (6 SD) decreased the amount of ripples detected in both genotypes to similar low levels. (B) The number of spikes per cell per ripple and the participation of individual cells in ripple events were significantly lower in CA1 pyramidal cells of Dp16 mice even when ripple events were detected using a more permissive threshold (2 SD). A similar effect was seen using a more restrictive threshold (6 SD), even though the decrease in participation rate in Dp16 mice did not reach the significance level. Using either the more restrictive or more permissive threshold for the detection of ripples, the proportion of cells plotted as a function of their participation rate in sharp-wave ripples confirmed a significant shift toward lower participation rates in Dp16 mice. Statistical significance was assessed using one-way ANOVA (A) or Mann-Whitney U-test and chi square text (B) with significance set at (*) p<0.05, (**) p<0.01 and (***) p<0.001.