Figure 1. Fluorescence in situ hybridization mapping of SLAMF7 gene on normal metaphase and MM cells.

(Sakamoto N, Taniwaki M et al., unpublished). FISH is performed as described as previously.⁹⁸ (A) Representative mapping finding of SLAMF7 gene on a partial metaphase cell using BAC clone RP11-404F10 containing SLAMF2, SLAMF7, and SLAMF3. (B) An enlarged view of chromosomes 1 shown in (A). SLAMF7 gene is assigned to 1q21.3 in our FISH study, although reportedly to be at the chromosomal band 1q23.3. (C) (D) Amplification of SLAMF7 gene in a metaphase spread and interphase nuclei obtained from a MM patient harboring pseudodiploid karyotype with 1q gain.