Figure 4. Chromosomal abnormalities in a patient with t(11;14)-positive primary refractory PCL detected by multicolor spectral karyotyping (SKY).

(Goto M, Taniwaki M, et al. unpublished). SKY is performed as described as previously.⁹⁸ Arrows indicate a balanced translocation t(11;14)(q13;q32). Three secondary CA are detected in this patient: der(1)t(1;16)(q10;p10) indicated by an arrowhead, monsomy 13 (−13), and der(17)t(4;17)(?;p13) indicated by a double arrowhead. Unbalanced translocations, der(1)t(1;16)(q10;p10) and der(17)t(4;17)(?;p13), result in 1q gain and 17p deletion, respectively, which are high-risk secondary CA in MM (Goto M, Taniwaki M, et al. unpublished).