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. 2018 Mar 1;13:1241–1256. doi: 10.2147/IJN.S158290

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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In vivo tumor targeting and distribution of MSNs-anti-miR-155@PDA-Apt in nude mice after intravenous injection. (A) Time-lapse NIR fluorescence images of nude mice at 1, 6, 12, and 24 hours postinjection. (B) The NIR fluorescence intensity in tumors quantified at indicated time points. (C) Ex vivo NIR fluorescence images of tumors and major organs at 24 hours. (D) Semiquantitative biodistribution of fluorescence intensity in tumors and major organs at 24 hours. Data are expressed as mean ± SEM (*P<0.05, **P<0.01).

Abbreviations: MSNs, mesoporous silica nanoparticles; PDA, polymerized dopamine; Apt, aptamer; NIR, near infrared; SEM, standard error of mean; miR-155, MicroRNA-155.