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. 2018 Mar 1;13:1241–1256. doi: 10.2147/IJN.S158290

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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Combined antitumor therapy of MSNs-anti-miR-155@PDA-Apt and 5-FU in vitro and in vivo. The viability of SW480 (A) and SW480/ADR (B) cells treated with free 5-FU, free 5-FU/MSNs@PDA-Apt, and free 5-FU/MSNs-anti-miR-155@PDA-Apt detected by MTT. Data are expressed as mean ± SEM (*P<0.05) (C) Western blot analysis of P-gp. (D) Image of nude mice with SW480 tumor 14 days after treatment. (E) Image of tumors 14 days after treatment.

Abbreviations: OD, optical density; 5-FU, 5-fluorouracil; MSNs, mesoporous silica nanoparticles; PDA, polymerized dopamine; Apt, aptamer; P-gp, p-glycoprotein; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SEM, standard error of mean; miR-155, MicroRNA-155.