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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Nat Genet. 2017 Apr 24;49(6):834–841. doi: 10.1038/ng.3841

Figure 3.

Figure 3

Effects and 95% confidence intervals of genetically predicted AAM on risks for various sex-steroid-sensitive cancers, adjusted for the effects of the same AAM variants on BMI. AAM was predicted by all 375 autosomal AAM-associated SNPs, and models were adjusted for the genetic effects of the same AAM variants on BMI. Three further genetic score associations are shown as sensitivity analyses for each outcome: first, AAM predicted by the 314 AAM-associated SNPs that were not also associated with BMI in the BCAC iCOGS sample (at a nominal level of P < 0.05); second, AAM predicted by the 61 AAM-associated SNPs that were also associated with BMI in this sample; and, third, AAM predicted by all 375 autosomal AAM-associated SNPs (unadjusted for BMI).