Skip to main content
. 2018 Feb 20;22(8):2094–2106. doi: 10.1016/j.celrep.2018.01.070

Figure 5.

Figure 5

SNPs Associated with Autoimmune Diseases Overlap with HIC1 Binding Sites and Alter the HIC1 DNA Binding Ability

(A) Enrichment of autoimmune-associated SNPs at HIC1 binding sites compared with a random set of background SNPs.

(B) SNPs overlapping the HIC1 motif (Experimental Procedures). rsID, overlapping SNP ID; proxyTo, lead SNP to which overlapping SNP is a proxy; Chr, chromosome; location, SNP location; major, major allele; minor, minor allele; disease, disease to which lead SNP is attributed; motif, motif sequence (SNPs in red); motifStart, location of motif start; motifStrand, strand info.

(C) Two DNA sequences with HIC1 binding site (HIC1 wild-type [WT]) and corresponding negative control DNA sequences in which the HIC1 motif has been mutated (HIC1 MT) were used as controls (Table S5). Data shown here are a representative of three biological replicates. Significance was determined with one-tailed paired t test. ∗p < 0.05.