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. 2018 Feb 20;22(8):2066–2079. doi: 10.1016/j.celrep.2018.01.089

Figure 1.

Figure 1

Mitochondrial Network Morphology of PD-OPA1, Normal Donor (ND), and OPA1-Complemented NPCs

(A–G) Representative images of mitochondrial morphology stained with TOMM20 (green) in PD-OPA1 (B–D), ND (A), and OPA1-complemented (E–G) NPCs.

(H) Quantification of mitochondrial morphology confirming the fragmented morphology in PD-OPA1 compared with ND and OPA1-complemented NPCs.

(I and J) Transmission electron microscopy (TEM) images (I) showing the mitochondria-altered morphological aspect. The mitochondrial size was calculated by measuring the perpendicular axis with respect to the larger diameter for all the mitochondria (200 mitochondria in total) and relative quantifications (J).

Data are mean ± SEM, n = 3 independent experiments. ∗∗p < 0.01, ∗∗∗p < 0.001 for ND NPCs and °°p < 0.01, °°°p < 0.001 for OPA1-complemented NPCs. Statistical analysis was performed using one-way ANOVA followed by Tukey post-test. Scale bars, 100 μm (A–G), 500 nm (I).