. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Am J Geriatr Psychiatry. 2017 Apr 25;25(10):1150–1159. doi: 10.1016/j.jagp.2017.04.013

Table 1. Characteristics of Subjects across all Studies at Baseline.

Subjects are classified as Alzheimer’s Disease (AD), mild cognitive impairment (MCI), or normal (NL) at the time of study entry. HS=high school.

	AD				MCI				NL
	N	African American (N=232)	White (N=3304)	P Value	N	African American (N=50)	White (N=1147)	P Value	N	African American (N=94)	White (N=729)	P Value
Age, years	3525	74.75+/− 8.49	75.40+/− 8.43	F_1,3523=1.45 p=0.228	1197	73.42+/− 8.25	73.92+/− 7.23	F_1,1195=0 p=0.953	823	76.21+/− 5.91	76.62+/− 6.26	F_1,821=0.3 p=0.587
Education, less than HS	3536	34% (78)	14% (454)	$χ_{2}^{2} = 73.8$ p<0.001	1197	22% (11)	8% (88)	$χ_{2}^{2} = 13.9$ p<0.001	823	18% (17)	4% (32)	$χ_{2}^{2} = 37.3$ p<0.001
HS graduate		47% (109)	51% (1680)			40% (20)	39% (452)			48% (45)	37% (273)
College graduate		19% (45)	35% (1170)			38% (19)	53% (607)			34% (32)	58% (424)
Ethnicity, Hispanic	3536	1% (3)	2% (73)	$χ_{2}^{2} = 0.87$ p=0.648	1197	0% (0)	1% (8)	$χ_{2}^{2} = 0.53$ p=0.768	823	0% (0)	0% (1)	$χ_{2}^{2} = 0.52$ 0.772
Not Hispanic		98% (228)	97% (3216)			100% (50)	99% (1135)			100% (94)	99% (725)
Unknown		0% (1)	0% (15)			0% (0)	0% (4)			0% (0)	0% (3)
Marital Status, Married	3536	45% (105)	71% (2353)	$χ_{4}^{2} = 83.1$ p<0.001	1196	42% (21)	78% (894)	$χ_{3}^{2} = 39.3$ p<0.001	823	32% (30)	63% (456)	$χ_{4}^{2} = 41.3$ p<0.001
Widowed		41% (94)	23% (751)			30% (15)	14% (161)			45% (42)	23% (169)
Divorced		12% (28)	4% (128)			22% (11)	6% (65)			16% (15)	9% (66)
Never married		2% (5)	2% (67)			6% (3)	2% (26)			5% (5)	5% (37)
Unknown		0% (0)	0% (5)			0% (0)	0% (0)			2% (2)	0% (1)
Sex, female	3536	71% (165)	58% (1902)	$χ_{1}^{2} = 16.4$ p<0.001	1197	62% (31)	42% (481)	$χ_{1}^{2} = 7.88$ p=0.005	823	77% (72)	56% (411)	$χ_{1}^{2} = 14$ p<0.001
placebo Treatment in Original Study, placebo	3361	44% (93)	48% (1521)	$χ_{1}^{2} = 16.4$ p=0.263	1167	77% (37)	61% (677)	$χ_{1}^{2} = 5.33$ p=0.021	811	100% (93)	100% (718)	---
Number of Organ Systems Affected	3536	5.09+/− 3.15	5.77+/− 3.00	F_1,3534=16.5 p<0.001	1197	5.66+/− 2.96	5.86+/− 2.67	F_1,1195=0.61 p=0.436	823	5.56+/− 2.72	6.24+/− 2.61	F_1,821=5.33 p=0.021
ADAS-cog, baseline	2578	26.4+/− 11.7	25.8+/− 10.9	F_1,2576=0.63 p=0.428	943	10.10+/− 3.59	11.36+/− 4.39	F_1,941=1.33 p=0.249	245	6.89+/− 3.40	5.91+/− 2.85	F_1,243=1.33 p=0.25
Month 6	2145	27.6+/− 11.8	27.0+/− 11.6	F_1,2143=0.55 p=0.459	817	9.19+/− 3.79	11.30+/− 5.34	F_1,815=3.07 p=0.08	148	6.81+/− 3.46	5.88+/− 2.80	F_1,146=0.61 p=0.436
Month 12	1851	28.1+/− 12.5	28.7+/− 12.4	F_1,1849=0 p=0.963	763	9.43+/− 4.55	11.91+/− 5.99	F_1,761=3.02 p=0.083	141	5.76+/− 2.95	5.68+/− 2.87	F_1,139=0.01 p=0.928
Month 18	1150	29.2+/− 13.5	30.6+/− 13.2	F_1,1148=0.51 p=0.475	683	9.17+/− 3.21	12.63+/− 6.82	F_1,681=4.37 p=0.037	---^*	---^*	---^*	---^*
Month 24	278	38.9+/− 11.8	36.1+/− 14.1	F_1,276=0.76 p=0.383	642	10.87+/− 4.74	12.99+/− 7.16	F_1,640=1.21 p=0.271	134	8.20+/− 5.26	5.67+/− 3.03	F_1,132=0.95 p=0.331

Statistical tests are shown with the degrees of freedom in subscripts.

Studies did not collect information on this subgroup at this time point.