Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Suggested model for the P. acnes infection phenotype of Modic changes. Disc damage is a prerequisite for P. acnes to invade the disc. Inside the disc, P. acnes proliferate and release virulence factors. Disc cells release cytokines as response to P. acnes. Free fatty acids are the consequence of lipase activity and are highly pro-inflammatory. This cocktail drains into the bone marrow, triggers a pro-inflammatory response in bone marrow cells, and may eventually cause Modic changes.
