Table 3.

Risk factors associated with 14-day seizure recurrence on bivariable analysis (N=366)^*

Risk factor	Risk of 14-day seizure recurrence if risk factor present	Risk of 14-day recurrence if risk factor absent	Relative Risk (95% CIs)
Age, n/N (%)
<12 months	21/74 (28.4%)	37/292 (12.7%)	2.2 (1.4, 3.6)**
<36 months	32/147 (21.8%)	26/219 (11.9%)	1.8 (1.1, 2.9)**
Male, n/N (%)	36/191 (18.8%)	22/175 (12.6%)	1.5 (0.9, 2.4)
Prior medical history, n/N (%)
Any CNS insult / abnormality predisposing to seizure***	1/22 (4.5%)	57/344 (16.6%)	0.3 (0.04, 1.9)
Motor or language delay, cerebral palsy/mental retardation	1/15 (6.7%)	57/351 (16.2%)	0.4 (0.06, 2.8)
Prior febrile seizures	1/17 (5.9%)	50/298 (16.8%)	0.4 (0.05, 2.4)
Seizure specific history, n/N (%)
More than 1 seizure in prior 24 hours	17/69 (24.6%)	40/289 (13.8%)	(1.1, 2.9)**
Longest seizure in prior 24 hours
≥5 min	10/73 (13.7%)	42/248 (16.9%)	0.8 (0.4, 1.5)
≥15 min	1/18 (5.6%)	51/303 (16.8%)	0.3 (0.05, 2.3)
Any focal aspect to seizure****	23/126 (18.3%)	32/207 (15.5%)	1.2 (0.7, 1.9)
Asleep (fully) at seizure onset	7/45 (15.6%)	40/238 (16.8%)	0.9 (0.4, 1.9)
Neurologic examination, n/N (%)
Abnormal mental status	9/62 (14.5%)	45/293 (15.4%)	0.9 (0.5, 1.8)
Abnormal overall neurologic exam other than mental status	5/29 (17.2%)	48/320 (15.0%)	1.1 (0.5, 2.7)
Any focal neurologic findings on exam	4/13 (30.8%)	53/349 (15.2%)	2.0 (0.9, 4.8)

^*Analysis based on high estimate for the 14-day seizure recurrence time point

^**p < 0.05 on bivariable analysis; no other variables in table with p < 0.1 on bivariable analysis

^***Defined as having a history of any of the following: birth injury, brain malformation, meningitis or encephalitis, post-natal head trauma requiring hospitalization, motor or language delay, cerebral palsy, mental retardation, or stroke.

^****Defined as motor aspect 1-sided or head or eyes turned to 1 side at any point

CNS – central nervous system