Table 1.
Chemical agents used to target chromatin modification enzymes.
| Compound | Target enzyme | Concentrations(μM) | Treatment period | Source | References | |
|---|---|---|---|---|---|---|
| Low | High | |||||
| Inhibition of DNA methyltransferases (DNMT) | ||||||
| 5-Azacytidine |
|
1 | 5 | 4 days | * | (Chernov et al., 2009, Zhang et al., 2011, Hassler et al., 2012) |
| (−)-Epigallocatechin gallate (EGCG) |
|
5 | 10 | 2 days | * | (Achour et al., 2013, Saldanha et al., 2014) |
| Inhibition of Histone Deacetylases (HDACs) | ||||||
| Trichostatin A |
|
0.05 | 0.1 | 4 days | * | (Mogal et al., 2006, Chang et al., 2012) |
| Apicidin |
|
0.5 | 1 | 1 day | * | (Ahn et al., 2012, Bauden et al., 2015) |
| Inhibition of Histone phosphorylation | ||||||
| PF-03814735 |
|
0.25 | 0.5 | 2 days | * | (Hook et al., 2012) |
| Inhibition of Histone Acetyltransferases (HATs) | ||||||
| Curcumin |
|
25 | 50 | 2 hours | * | (Balasubr amanyam et al., 2004, Ahn et al., 2012) |
| Inhibition of Histone Methyltransferases (HMTs) | ||||||
| BIX 01294 |
|
0.5 | 1 | 2 days | * | (Kubicek et al., 2007) |
| Inhibition of Histone Demethylases (HDMs) | ||||||
| Tranylcypromine, HCl (TCP) |
|
2 | 5 | 4 days | # | (Nebbioso et al., 2012) |
*
Sigma-Aldrich, St. Louis, MO, USA
#
EMD Millipore, Temecula, CA, USA