Table 3.
Similarities and differences between prior prospective cohort of children with mean nocturnal oxygen saturation demonstrating increased incidence of severe pain days7 and the current multi-Sleep and Asthma Cohort (SAC) study, demonstrating no increase incidence rates of acute pain episodes requiring hospitalization.
| Hargrave et al. | Sleep and Asthma Cohort (SAC) | |
|---|---|---|
| Sample size | N = 95 | N = 140 |
| Number of institutions involved in the study | Single institution | Multi-institution (3 large pediatric centers) |
| Management of hydroxyurea | Excluded from all analyses | Excluded from all analyses |
| Definition of pain | Hospital treatment (emergency department visit or hospital admission) | Hospital admission only |
| Outcome measurement used | Hospital days for pain per years of follow-up | Incidence rate of hospitalization for acute pain per patient year |
| Measurement of oxygen saturation | Pulse oximetry at home (N = 63) or in laboratory (N = 27) | Full 12-channel, in-laboratory research polysomnography with central adjudication (N = 140) |
| Pulse oximetry machine used | Ohmeda Biox 3700 | Masimo SET (v2) |
| Measurement modality | Pulse oximetry (SpO2) | Pulse oximetry (SpO2), oxygen desaturation index (ODI), and obstructive apnea hypopnea index (OAHI) |
| Statistical analysis | Multiple linear regression without adjustment for collinearity | Multiple negative binomial regression with tests for collinearity |