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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Int Forum Allergy Rhinol. 2017 Nov 28;8(3):415–420. doi: 10.1002/alr.22053

Figure 3. Induced chronic inflammation cause OSN apoptosis.

Figure 3

(A) Q-PCR analysis of IL-1β mRNA expression. Compared to control mice, the inflammatory cytokine IL-1β was upregulated 32-fold in olfactory mucosa derived from Dox treated IOI mice. IOI mice were treated with Dox for 3 weeks (n = 3). *P = 0.0001.

(B) Quantification of Caspase-3+ apoptosis in olfactory sensory neurons (OSNs).

(C) Representative confocal images of caspase-3 immunostaining. IOI mice were treated with Dox for 3 weeks (n = 3). Scale bar, 20 μm.