Table 4.

Correlation of the HIT-6 and PROMIS short forms with HCV-PRO and MSAS items (N=961)

Measure	Corresponding Measure	Na	Correlationb	95% C.I.c
HIT-6 scored	HCV-PRO Item: I felt bothered by pain or physical discomfort	935	0.45	[0.39, 0.50]
	MSASe pain score	936	0.37	[0.31, 0.43]
PROMIS T–scored
Fatigue	HCV-PRO Item: I felt too tired during the day to get done what I needed	958	0.74	[0.70, 0.77]
	MSAS lack of energy score	949	0.77	[0.74, 0.80]
Pain Interference	HCV-PRO Item: I felt bothered by pain or physical discomfort	951	0.74	[0.70, 0.77]
	MSAS pain score	952	0.76	[0.73, 0.79]
Sleep Disturbance	HCV-PRO Item: I had difficulty sleeping or slept too much	954	0.74	[0.71, 0.78]
	MSAS difficulty sleeping score	949	0.77	[0.75, 0.80]
Depression	HCV-PRO Item: I felt downhearted and sad	951	0.67	[0.63, 0.71]
	MSAS feeling sad score	949	0.64	[0.60, 0.68]
Cognitive Concerns	HCV-PRO Item: I was unable to think clearly or focus on my thoughts	957	0.78	[0.75, 0.81]
	MSAS difficulty concentrating score	951	0.67	[0.64, 0.71]
Anger	HCV-PRO Item: I felt restless or on edge	952	0.62	[0.58, 0.67]
	MSAS feeling irritable score	943	0.58	[0.54, 0.63]
Anxiety	HCV-PRO Item: Having Hepatitis C was very stressful to me	948	0.48	[0.43, 0.53]
	MSAS feeling nervous score	941	0.56	[0.51, 0.61]
	MSAS worrying score	939	0.61	[0.57, 0.66]
Belly Pain	HCV-PRO Item: I felt bothered by pain or physical discomfort	950	0.48	[0.42, 0.53]
	MSAS pain score	951	0.39	[0.34, 0.45]
Diarrhea	MSAS diarrhea score	937	0.51	[0.46, 0.57]
Nausea/Vomiting	MSAS nausea score	939	0.64	[0.60, 0.69]
	MSAS vomiting score	940	0.35	[0.29, 0.40]

Note:

^aThe number of participants with a non-missing value.

^bAbsolute value of Spearman’s rank correlation coefficient between each measure and a similar construct.

^c95% confidence interval (C.I.)for Spearman’s rank correlation coefficient.

^dHigher values on the HIT-6 and PROMIS scores indicate more severe symptoms.

^eMSAS = Memorial Symptom Assessment Scale. MSAS score = average of the three attributes: severity, frequency, and interference.