Table 5.
Known-Groups Validity: PROs scores by liver disease status
| Group A | Group B | |||
|---|---|---|---|---|
|
| ||||
| Measure | No cirrhosis N=456a |
Cirrhosis (MELD 6–11) N=334b |
Cirrhosis (MELD≥12) N=37c |
Group A – Group Bd |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean Difference (95% CI) | |
| HIT-6 scoree | 46 (11) | 45 (10) | 47 (11) | −1.5 [−4.9, 2.0] |
| PROMIS T-scorese | ||||
| Fatigue | 52 (11) | 52 (11) | 54 (10) | −1.9 [−5.6, 1.7] |
| Pain Interference | 53 (12) | 53 (11) | 56 (10) | −3.0 [−6.7, 0.7] |
| Sleep Disturbance | 52 (11) | 52 (12) | 54 (10) | −2.4 [−6.2, 1.4] |
| Depression | 50 (11) | 49 (11) | 54 (9) | −4.1 [−7.6, −0.6] |
| Cognitive Concerns | 33 (9) | 33 (9) | 35 (8) | −1.8 [−4.9, 1.2] |
| Anger | 49 (12) | 48 (11) | 51 (10) | −2.9 [−6.7, 0.8] |
| Anxiety | 51 (11) | 49 (10) | 54 (10) | −3.5 [−6.9, 0.0] |
| Belly Pain | 37 (13) | 37 (13) | 40 (14) | −3.3 [−7.7, 1.1] |
| Diarrhea | 36 (9) | 35 (8) | 39 (12) | −3.8 [−7.7, 0.2] |
| Nausea/Vomiting | 42 (9) | 42 (9) | 46 (9) | −3.9 [−6.8, −1.0] |
| HCV-PROf | 71 (23) | 71 (23) | 63 (23) | 7.7 [0.0, 15.3] |
Note: SD=Standard Deviation; CI=Confidence Interval
a
Sample size ranges from 415–456.
b
Sample size ranges from 312–334.
c
Sample size ranges from 36–37.
d
Group A = No cirrhosis or mild cirrhosis (MELD 6–12), Group B = Advanced Cirrhosis(MELD>12).
e
Higher values indicate more severe symptoms.
f
Higher values indicate higher functional well-being.