Skip to main content
. Author manuscript; available in PMC: 2018 Mar 8.
Published in final edited form as: Leukemia. 2017 Nov 16;32(3):850–854. doi: 10.1038/leu.2017.325

Figure 1.

Figure 1

Mutant p53 enhances the repopulating potential of bone marrow cells. (a) The frequency of LT-HSCs, ST-HSCs, MPPs, and LSKs in the BM of young p53+/+ and p53R248W/+ mice. n=10 mice per genotype. (b) The frequency of CMPs, MEPs, GMPs, and Lin−Kit+ cells in the bone marrow of young p53+/+ and p53R248W/+ mice. n=10 mice per genotype. (c) Percentage of donor-derived (CD45.2+) cells in the peripheral blood of primary recipient mice post-transplantation, measured at 4-week intervals. **p<0.01, ***p<0.001, n=7 mice per group. (d) The frequency of donor-derived LT-HSCs, ST-HSCs, MPPs, and LSKs in the bone marrow of primary recipient mice 16 weeks following transplantation. *p<0.05, ***p<0.001, n = 7 mice per group. (e) The frequency of donor-derived MEPs, CMPs, GMPs, and myeloid progenitors (Lin−Kit+) in the bone marrow of primary recipient mice 16 weeks following transplantation. *p<0.05, **p<0.01, n = 7 mice per group. (f) The percentage of donor-derived myeloid cells (Gr1+), B cells (B220+), and T cells (CD3e+) in the peripheral blood of primary recipient mice 16 weeks following transplantation. n=7 mice per group. (g) The percentage of donor-derived myeloid cells, B cells, and T cells in the bone marrow of primary recipient mice 16 weeks following transplantation. n = 7 mice per group. (h) The percentage of donor-derived cells in the peripheral blood of secondary recipient mice. ***p<0.001, n=7 mice per group. (i) The percentage of donor-derived myeloid cells, B cells, and T cells in the peripheral blood of secondary recipient mice 16 weeks following transplantation. n=7 mice per group. (j) The percentage of donor-derived cells in the peripheral blood of secondary recipients 48 weeks after transplantation. ***p<0.001, n=7 mice per group. (k) The percentage of donor-derived myeloid cells, B cells, and T cells in the peripheral blood of secondary recipient mice 48 weeks after transplantation. *p<0.05, **p<0.01, n=7 mice per group.