Table 1.
EC50 (nM) | E max (%) | |
---|---|---|
Human | ||
Vehicle | 104 ± 60 | 16 ± 2 |
LUF6096 | 405 ± 124* | 25 ± 2* |
Dog | ||
Vehicle | 3971 ± 197 | 23 ± 2 |
LUF6096 | 10,260 ± 1766* | 64 ± 5* |
Rabbit | ||
Vehicle | 280 ± 24 | 20 ± 4 |
LUF6096 | 233 ± 109 | 60 ± 6* |
Mouse | ||
Vehicle | 3643 ± 408 | 21 ± 4 |
LUF6096 | 3169 ± 117 | 15 ± 2 |
EC50 and E MAX values (mean ± SEM; n = 5–8 performed in quadruplicate) calculated from concentration-response curves, as described in “Materials and methods”
*P < 0.05 vs. vehicle