Table 1.

Effect of LUF6096 on adenosine-induced [³⁵S]GTPγS binding

	EC50 (nM)	E max (%)
Human
Vehicle	104 ± 60	16 ± 2
LUF6096	405 ± 124*	25 ± 2*
Dog
Vehicle	3971 ± 197	23 ± 2
LUF6096	10,260 ± 1766*	64 ± 5*
Rabbit
Vehicle	280 ± 24	20 ± 4
LUF6096	233 ± 109	60 ± 6*
Mouse
Vehicle	3643 ± 408	21 ± 4
LUF6096	3169 ± 117	15 ± 2

EC₅₀ and E _MAX values (mean ± SEM; n = 5–8 performed in quadruplicate) calculated from concentration-response curves, as described in “Materials and methods”

*P < 0.05 vs. vehicle