Fig. 2.

Intrathecal treatment with a shRNA against P2Y₁₂ receptor relieves mechanical and thermal hyperalgesia in gp120+ddC-treated rats. a The mechanical withdrawal threshold in the gp120+ddC group was lower than in the control group (p < 0.01). No difference was found between the sham group and the control group (p > 0.05). In gp120+ddC rats treated with P2Y₁₂ receptor shRNA, the mechanical withdrawal threshold was higher than in the gp120+ddC group that did not receive P2Y₁₂ receptor shRNA (p < 0.01). No difference was found between the gp120+ddC+NC group and the gp120+ddC group (p > 0.05). Each group consisted of eight rats. Data are displayed as the means ± SE. *p < 0.05 compared to the control group; **p < 0.01 compared to the control group; #p < 0.05 compared to the gp120+ddC-treated group; ##p < 0.01 compared to the gp120+ddC-treated group. b The thermal withdrawal latency in the gp120+ddC group was gradually shorter than in the sham group (p < 0.05 or p < 0.01). No difference was found between the sham group and the control group (p > 0.05). In gp120+ddC rats treated with P2Y₁₂ receptor shRNA, the thermal withdrawal latency was higher than in the gp120+ddC group (p < 0.01). No difference was found between the gp120+ddC+NC group and the gp120+ddC group (p > 0.05). Each group consisted of eight rats. The data are displayed as the means ± SE. *p < 0.05 compared to the sham group; **p < 0.01 compared to the sham group; #p < 0.05 compared to the gp120+ddC-treated group; and ##p < 0.01 compared to the gp120+ddC-treated group