Fig. 3.

Intrathecal treatment with a shRNA against P2Y₁₂ receptor reduces the upregulation of P2Y₁₂ receptor and GFAP co-localization values in the DRG of gp120+ddC-treated rats. Co-localization of P2Y₁₂ receptor and GFAP in the gp120+ddC group was higher than in the sham group. No difference was found between control and sham rats. Silencing of P2Y₁₂ receptor reduced the co-localization values of P2Y₁₂ receptor and GFAP in gp120+ddC+P2Y₁₂ receptor shRNA-treated rats compared with gp120+ddC-treated rats that did not receive P2Y₁₂ receptor shRNA. There was no significant difference between the gp120+ddC group and the gp120+ddC+NC group