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. 2017 Dec 18;12(1):231–243. doi: 10.1007/s12079-017-0440-4

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — An enhancer -198 kb upstream of CCN2 drives transgene activity within tissue of mesenchymal origin. Strong transgene expression was observed within dermal mesenchyme globally including within the dorsal (a and d) and craniofacial (c) regions. Further fibroblastic activity was also observed within the tendons of the hind paw (b). Hypertrophic chondrocytes stained strongly in a global manner including within the basioccipital bone and atlas (e), scapula (g), humerus (h) and hind limb (k). Staining within other types of chondrocytes was limited, with additional activity within articular chondrocytes such as in the hip (j, black arrowhead). Punctate staining was observed within the chondrocranium (c and f) whereas the vertebrae (l) and intervertebral disc (black arrowhead) were negative for transgene activity. There was however, some staining within osseous tissue including within the primary ossification centre within the scapula (h, os), humerus (h, os) and iliac bone (i), this was not present in the ossified region of the orbital plate of the frontal bone (c, black arrowhead) (Bar = 100 μm)