Fig. 3. Rap1 deficiency in MSCs impairs their ability as immune adjuvants of rapamycin.
a Graft survival was shown by Kaplan–Meier method and compared by log-rank test (n = 16 for each group). #p < 0.05 vs. L_RAPA + Rap1−/−-MSC group. b WBC and PLT count were measured at 48 h after transplantation (n = 6 for each group). c Cell engraftment in the transplanted heart was determined by GFP-positive cell sorting (n = 3 for each group). *p < 0.05; N: non-significance, WBC: white blood cell, PLT: platelet.