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. 2018 Mar 7;9(3):386. doi: 10.1038/s41419-018-0414-3

Fig. 4. Rap1 deficiency decreases the immunosuppressive ability of MSCs in vivo.

Fig. 4

a Representative photographs showing the ISHLT score for each group (i) and typical H&E staining of grafts (ii) (n = 6 for each group). Scale bar = 100 μM. b Quantification of infiltrating CD45+ mononucleocyte population in cells isolated from transplanted hearts at 48 h after surgery by FACS analysis (n = 3 for each group). c Proportions of splenic and allograft transplant CD4+Foxp3+ Treg cells were analyzed by flow cytometry at day 2 post transplantation (n = 3 for each group). d The concentration of IFN-γ, TNF-α, IL-6, IL-10, and TFG-β in sera from rejected hearts was measured by Flowcytomix (n = 10 for each group). *p < 0.05; **p < 0.01; ***p < 0.001; N: non-significance.