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Genes detected in HDGC and their related information

Genes	Corresponding proteins	Functions	Cancers in which the related genes express	Ref.
HDGC, hereditary diffuse gastric cancer; DGC, diffuse gastric cancer.
CDH1	E-cadherin	Adhesion in cell-cell and tumor suppressor	Gastric cancer (including HDGC); breast cancer; pancreatic ductal adenocarcinoma; colorectal cancer; hepatocellularcarcinoma; squamous cell carcinomas of the skin, head and neck; esophageal carcinoma; and melanoma	3,26-44
CTNNA1	Alpha-E-cadherin	Adhesion in cell-cell and tumor suppressor	HDGC, colorectal cancer	24,26,46,47
INSR	Receptor tyrosine kinase	Affect tumor cell invasion	HDGC	25
FBXO24	F-box protein	Lead to malignancies	DGC	1,25
DOT1L	Histone methyltransferase	May has an effect on DNA repair	DGC	1,25
MAP3K6	A serine/threonine protein kinase	As a tumor suppressor	HDGC	1,48
CD44	A cell-surface glycoprotein	Functions in cell-cell interactions, cell adhesion and migration	Hyperplastic polyps, intestinal metaplasia, dysplasia, gastric cancer, gastric cancer (including HDGC)	49
PALB2, BRCA1, RAD51C	Corresponding proteins of their own	Regulate homologous DNA recombination	HDGC, breast cancer	50
MET	A protein with an extracellular, transmembrane and a tyrosine kinase domain	Functions in cellular survival, embryogenesis, and cellular migration and invasion	Hereditary papillary renal carcinoma, family gastric cancer, breast, prostate, ovarian cancers	51