Table 3.
Univariate and Multivariate Analysis of Factors Associated with Overall Survival in 107 Pancreatic Cancer Patients
| Characteristics | Univariate Analysis |
Multivariate Analysis |
||
|---|---|---|---|---|
| HR (95% CI) | p Values | HR (95% CI) | p Values | |
| Gender (male) | 1.08 (0.72–1.62) | 0.719 | 1.02 (0.65–1.60) | 0.930 |
| Age (≥ 60 years) | 1.06 (0.70–1.61) | 0.782 | 1.38 (0.87–2.19) | 0.176 |
| Histopathology (ductal ad.) | 1.25 (0.75–2.10) | 0.394 | 1.26 (0.70–2.26) | 0.435 |
| Location (head of pancreas) | 2.28 (1.38–3.77) | 0.001∗ | 1.62 (0.88–2.98) | 0.121 |
| Grade (poor) | 1.05 (0.68–1.64) | 0.815 | 0.83 (0.50–1.38) | 0.482 |
| T stage (T3–T4) | 2.48 (1.46–4.24) | 0.001∗ | 1.24 (0.61–2.53) | 0.549 |
| N stage (N1) | 1.85 (1.17–2.92) | 0.008∗ | 0.93 (0.50–1.71) | 0.810 |
| M stage (M1) | 0.98 (0.36–2.68) | 0.972 | 0.35 (0.11–1.10) | 0.072 |
| Clinical stage (III–IV) | 4.04 (2.07–7.89) | 4.04 | 2.55 (0.95–6.82) | 0.062 |
| IHC status of Ki67 (high) | 2.40 (1.57–3.69) | <0.001∗ | 1.82 (1.09–3.03) | 0.022∗ |
| IHC status of p53 (high) | 1.38 (0.91–2.09) | 0.127 | 1.27 (0.81–1.98) | 0.299 |
| miR-1266 (high) | 2.07 (1.36–3.14) | 0.001∗ | 1.83 (1.14–2.95) | 0.013∗ |
∗
p <0.05. HR, hazard ratio; CI, confidence interval; IHC, immunological histological chemistry.