Table 2.

Association between intensity of physical activity and CSF biomarkers

Biomarker	Sedentary		Light		Moderate		Vigorous
	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P
Aβ42	−54.12 (21.52)	.014	39.47 (22.35)	.081	60.74 (22.27)	.008	35.42 (23.45)	.135
t-tau	−2.89 (15.28)	.850	9.88 (15.53)	.526	−24.31 (15.68)	.125	−1.79 (16.25)	.913
p-tau	−1.45 (1.56)	.356	1.57 (1.59)	.327	−0.46 (1.63)	.779	−0.11 (1.67)	.947
t-tau/Aβ42	−0.05 (0.03)	.109	−0.03 (0.03)	.366	−0.09 (0.03)	.006	−0.05 (0.04)	.150
p-tau/Aβ42	0.01 (0.01)	.161	−0.01 (0.01)	.402	−0.01 (0.01)	.030	−0.01 (0.01)	.101

NOTE. Models were adjusted for age, sex, APOE ε4 status, interval between CSF collection and accelerometer data, and assay batch. The regression estimate (β) refers to the amount of change in each biomarker for every 1% change in time spent in each PA category. Bolded values refer to associations where P < .05. Italicized values refer to associations where .05 < P < .10.

Abbreviations: CSF, cerebrospinal fluid; β, regression estimate; SE, standard error; Aβ42, amyloid β 42; t-tau, total tau; p-tau, phosphorylated tau; APOE ε4, apolipoprotein E ε4 allele.