3.
Univariate analysis for DFS and OS
| Item | DFS | OS | |||||
| P | HR | 95% CI | P | HR | 95% CI | ||
| DFS: disease-free survival; OS: overall survival; HR: hazard ratio; CI: confidence interval; SqCC: squamous cell carcinoma; F-NLR: combination of fibrinogen concentration and neutrophil to lymphocyte ratio; NLR: neutrophil to lymphocyte ratio; LDH: lactate dehydrogenase; WBC: white blood cell; ALP: alkaline phosphatase; Hb: hemoglobin. | |||||||
| Age, years (≤ 60, >60) | 0.478 | 1.085 | 0.866–1.360 | 0.391 | 1.104 | 0.881–1.384 | |
| Gender (male, female) | 0.714 | 0.956 | 0.751–1.217 | 0.355 | 0.892 | 0.701–1.136 | |
| Smoking (yes, no) | 0.783 | 0.967 | 0.761–1.229 | 0.375 | 0.897 | 0.705–1.141 | |
| Histology (adenocarcinoma, SqCC, others) | 0.109 | 1.146 | 0.970–1.353 | 0.111 | 1.144 | 0.970–1.350 | |
| Tumor location (left, right) | 0.604 | 0.941 | 0.749–1.183 | 0.562 | 0.935 | 0.744–1.175 | |
| Lesion (peripheral, central) | 0.023 | 1.324 | 1.040–1.686 | 0.014 | 1.355 | 1.064–1.726 | |
| Resection type (pneumonectomy, lobectomy) | 0.041 | 1.400 | 1.013–1.933 | 0.038 | 1.407 | 1.019–1.943 | |
| Pathological stage (I, II, IIIA) | <0.001 | 1.788 | 1.569–2.038 | <0.001 | 1.783 | 1.564–2.031 | |
| Tumor size, cm (< 4, ≥4) | <0.001 | 1.796 | 1.415–2.281 | <0.001 | 1.755 | 1.382–2.228 | |
| Adjuvant chemotherapy (yes, no) | 0.138 | 1.187 | 0.946–1.488 | 0.217 | 1.153 | 0.920–1.445 | |
| Adjuvant radiotherapy (yes, no) | 0.001 | 1.685 | 1.235–2.300 | 0.004 | 1.571 | 1.151–2.143 | |
| F-NLR (0, 1, 2) | <0.001 | 1.644 | 1.431–1.888 | <0.001 | 1.647 | 1.434–1.891 | |
| NLR (≥2.30, <2.30) | <0.001 | 2.196 | 1.751–2.754 | <0.001 | 2.199 | 1.753–2.757 | |
| Fibrinogen (<3.48 g/L，≥ 3.48 g/L) | <0.001 | 1.707 | 1.352–2.155 | <0.001 | 1.733 | 1.373–2.188 | |
| LDH (≥195.5, <195.5 U/L) | 0.003 | 1.443 | 1.134–1.835 | 0.005 | 1.415 | 1.112–1.799 | |
| D-dimer (≥0.15, <0.15 mg/L) | <0.001 | 1.546 | 1.232–1.939 | 0.002 | 1.437 | 1.144–1.803 | |
| Neutrophil ratio (≥62.35, <62.35%) | <0.001 | 2.015 | 1.607–2.526 | <0.001 | 2.007 | 1.601–2.517 | |
| Monocyte ratio (≥8.97, <8.97%) | 0.008 | 1.399 | 1.093–1.791 | 0.006 | 1.412 | 1.103–1.807 | |
| Lymphocyte ratio (≤ 26.55, >26.55%) | <0.001 | 0.450 | 0.359–0.565 | <0.001 | 0.451 | 0.359–0.565 | |
| WBC count (≥7.805, <7.805×10 3/μL) | 0.007 | 1.386 | 1.092–1.760 | 0.008 | 1.379 | 1.087–1.751 | |
| Platelet count (≥202, <202×10 9/L) | 0.140 | 1.216 | 0.938–1.577 | 0.160 | 1.205 | 0.929–1.563 | |
| ALP (≥66.5, <66.5 U/L) | 0.002 | 1.465 | 1.152–1.862 | 0.003 | 1.430 | 1.126–1.818 | |
| Hb (≤137.5, >137.5 g/L) | 0.022 | 0.769 | 0.613–0.964 | 0.040 | 0.789 | 0.630–0.989 | |