4.

Multivariate analysis for DFS and OS

Item	DFS			OS
Item	P	HR	95% CI	P	HR	95% CI
DFS: disease-free survival; OS: overall survival; HR: hazard ratio; CI: confidence interval; F-NLR: combination of fibrinogen concentration and neutrophil to lymphocyte ratio; LDH: lactate dehydrogenase; WBC: white blood cell; ALP: alkaline phosphatase; Hb: hemoglobin.
Lesion (peripheral, central)	0.642	0.931	0.687–1.260	0.603	0.923	0.682–1.249
Resection type (pneumonectomy, lobectomy)	0.265	1.246	0.846–1.836	0.246	1.257	0.854–1.851
Pathological stage (I, II, IIIA)	<0.001	1.602	1.379–1.862	<0.001	1.648	1.419–1.914
Tumor size (< 4 cm, ≥4 cm)	0.951	0.991	0.751–1.309	0.878	0.978	0.741–1.292
Adjuvant radiotherapy (yes, no)	0.195	1.239	0.896–1.714	0.377	1.157	0.837–1.601
F-NLR (0, 1, 2)	<0.001	1.466	1.243–1.730	<0.001	1.512	1.283–1.783
LDH (≥195.5, <195.5 U/L)	0.186	1.196	0.917–1.560	0.294	1.152	0.885–1.500
D-dimer (≥0.15, <0.15 mg/L)	0.007	1.403	1.096–1.796	0.012	1.371	1.071–1.756
Monocyte ratio (≥8.97, <8.97%)	0.079	1.279	0.972–1.684	0.057	1.304	0.992–1.714
WBC count (≥7.805, <7.805×10 ³/μL)	0.564	1.080	0.832–1.402	0.687	1.055	0.812–1.370
ALP (≥66.5, <66.5 U/L)	0.071	1.283	0.979–1.683	0.093	1.260	0.962–1.650
Hb (≤137.5, >137.5 g/L)	0.337	0.887	0.695–1.133	0.302	0.879	0.688–1.123