Table 3.

Mean change scores compared with baseline

	Responders					Non-responders
	Day 7	Day 14	Day 30	Day 60	Day 90	Day 7	Day 14	Day 30	Day 60	Day 90
QLQ-C15-PAL
Fatigue∗	–7.43	–14.84‡	–9.90	–23.65‡	–21.01‡	8.56	–1.18	11.34	5.31	3.82
Appetite loss∗	–18.52‡	–18.52‡	–18.52‡	–23.81‡	–33.33‡	0.00	–12.5	12.50	–16.67	–13.33
Nausea and vomiting∗	–1.86	–9.27	–3.71	–11.91	–16.68 ‡	0.00	0.00	8.31	–4.87	–10.44
Constipation∗	0.00	–14.81	–22.22‡	–16.40	–14.81	5.36	13.69	9.52	–7.14	9.52
Pain∗	–14.82‡	–20.37‡	–24.07‡	–31.48‡	–25.93‡	4.17	0.00	6.25	–3.47	–21.25‡
Emotional functioning†	–3.70	–0.92	7.40	7.02	6.02	–8.03	–10.10	–5.94	–4.58	–4.29
Physical functioning†	11.11	13.33‡	8.14	13.96‡	22.21‡	0.81	0.83	–11.66§	–6.12	–1.02
QLQ-BM22
Painful sites∗	–10.62‡	–15.56‡	–14.07‡	–11.64‡	–10.37‡	7.22	–0.60	3.33	1.94	5.50
Painful characteristics∗	–15.43‡	–14.82‡	–16.05‡	–21.52‡	–13.58‡	13.82§	10.64	10.24	5.61	–8.09
Functional interference†	11.57‡	16.73‡	12.43‡	23.80‡	21.36‡	6.51	3.28	–4.24	–1.46	8.44
Psychosocial aspects†	4.32	3.55	–1.85	3.35	2.16	6.94	5.85	–0.70	–1.16	–0.97

Scores above the minimal clinically important differences (MCIDs) set by Raman et al.[24] are highlighted in bold. No MCIDs available for the dyspnoea, insomnia and overall quality of life scales.

^∗Increasing scores represent worsening quality of life.

^†Increasing scores represent improving quality of life.

^‡Clinically significant improvement.

^§Clinically significant deterioration.