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. 2017 Dec 21;192(1):82–94. doi: 10.1111/cei.13080

Figure 1.

Figure 1

Analysis of crucial genes involved in the insulin signalling pathway in rheumatoid arthritis synovial fibroblast‐like cells (RASFs) (n = 10) transfected with the anti‐TXNDC5 siRNA using (a) insulin signalling pathway and (b) insulin resistance polymerase chain reaction (PCR) arrays. Fold‐change values greater than 1 indicate a positive change or up‐regulation. Fold‐change values less than 1 indicate a negative change or down‐regulation. Fold‐change values greater than 2 are indicated in red, and fold‐change values less than 0·5 are indicated in green. (c) The PCR array results are depicted in one map. Five genes, specifically insulin‐like growth factor binding protein 1 (IGFBP1), phosphoenolpyruvate carboxykinase 1 (PCK1), solute carrier family 2, member 4 (SLC2A4), interleukin 1 receptor type 1 (IL‐1R1) and insulin‐like growth factor 1 (IGF‐1), with significantly altered expression, were detected in RASFs transfected with the anti‐TXNDC5 siRNA.