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. Author manuscript; available in PMC: 2019 Jan 15.
Published in final edited form as: Methods. 2017 Aug 31;133:44–53. doi: 10.1016/j.ymeth.2017.08.018

Figure 1. The model describing the influence of oxygen level on the proliferation and lineage specification of NPCs.

Figure 1

In the presence of growth factors (EGF and bFGF), the proliferation capacity of NPCs is higher in mild hypoxia (3–5% O2) than in 20% O2. Severe hypoxia (1–2% O2), however, slows down the proliferation of NPCs. In the absence of growth factors, the differentiation potential of NPCs is affected by different level of oxygen. Mild hypoxia promotes neurogenesis and oligodendrogenesis, whereas severe hypoxia favors the generation of astroglial lineage.