Table 1.

Incidences of NMBA-induced lesions in mouse esophagus, forestomach, and tongue^a, ^b

Group	Genotype	Treatment	No.	Esophagus			Forestomach			Tonguec
				Dysplasia	Papilloma	SCC	Dysplasia	Papilloma	SCC	Dysplasia	Papilloma	SCC
A	Wild-type	Liquid diet	18	0	0	0	22.2%	72.2%	5.6%	0	0	0
							(4/18)	(13/18)	(1/18)
B	Wild-type	Isocaloric diet with 6.4% v/v ethanol	24	4.2%	50%	0	16.7%	95.8%	8.3%	0	0	0
				(1/24)	(12/24)		(4/24)	(23/24)	(2/24)
					(P=0.0003)
C	Krt5Cre;Pax9loxP/loxP	Liquid diet	22	18.2%	77.3%	0	81.8%	90.9%	31.8%	4.5%	9.1%	22.7%
				(4/22)	(17/22)		(18/22)	(20/22)	(7/22)	(1/22)	(2/22)	(5/22)
					(P=0.0001)		(P=0.0003)		(P=0.046)			(P=0.053)

^aMicroscopically detected lesions including dysplasia, papilloma, and SCC were diagnosed according to established criteria.

^bAll P values were calculated by comparing with Group A and determined using Student’s t-test.

^cP=0.005 when tongue dysplasia, papilloma and SCC are combined for comparison.