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DOTA-PNA-Peptide Cu-64 radiolabeling and BT474 Cellular Uptake
| Target | HER2 Antisense | PNA Mismatch | Peptide Mismatch |
|---|---|---|---|
| Agent | WT4340 | WT4314 | WT4289 |
| Cu-64 radiochemical puritya | 98.80% | 94.90% | 98.30% |
| BT474 cell uptakeb | 17.78% | 8.84% | 8.80% |
| 25.49% | 8.71% | 9.13% | |
| 25.66% | 7.18% | 9.43% | |
| Mean value | 22.98±4.50% | 8.24±0.92% | 9.12±0.32% |
| Null probability | p<0.01 | p<0.01 |
C18 reversed phase chromatography.
scintillation counting of cell pellets
