Table 2.

Criteria for stopping TKIs from expert recommendations and guidelines

Criteria	Hughes* [52]			NCCN** [2]	ESMO** [53]
	Green	Yellow	Red
CML past history	CP only	Resistance or KD mutation	AP/BP	CP only	CP only
Sokal	Non-high	High	NA		Non-high
Response to TKI therapy	Optimal	Warning	Failure	No resistance	Optimal
BCR-ABL1 transcript	Typical	Quantifiable atypical	Not quantifiable	Measurable	Measurable
Duration TKI	≥ 8 years	3–8 years	< 3 years	≥ 3 years	≥ 5 years
DMR	≤ MR4.5	≤ MR4.0	> MR4.0	≤ MR4.0	≤ MR4.5
Duration DMR	≥ 2 years	1–2 years	< 1 year	≥ 2 years	≤ MR4 ≥ 2 years
Retreatment				Loss MMR
PCR sensitivity	≤ MR4.5				≤ MR4.5
Frequency of monitoring	Q1M 1st 6 months, Q2–3 months			Q1M × 6, Q6W × 6M, Q3M	Q1M × 6, Q6W × 6, Q3M
PCR result turnaround time	≤ 4 weeks			≤ 2 weeks

M months, W weeks

*Expert recommendations

**Guidelines