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. 2017 May 8;55(4):3270–3289. doi: 10.1007/s12035-017-0585-4

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Influence of the CUMS on the expression of nicotine-induced CPP in rats after 3 days of conditioning. Rats were subjected to the CUMS protocol for 21 days. Place preference procedure consisted of pre-conditioning, three conditioning sessions with nicotine (0.175 mg/kg, i.p.), and post-conditioning test. Data represent means ± S.E.M. and are expressed as the difference (in s) between post-conditioning and pre-conditioning time spent in the drug-associated compartment. n = 8–12 rats per group; ***P < 0.001 vs. unstressed saline-conditioned rats; ^P < 0.05 vs. stressed saline-conditioned rats (Tukey’s test)