Table 5.

Influence of imipramine (15 mg/kg) on the parameters of oxidative stress (TAC, GPx, SOD, MDA) within the whole brain and its structures (cortex, hippocampus, and cerebellum) in stressed rats after 2 days of saline or nicotine (0.175 mg/kg, i.p.) conditioning

Oxidative stress parameter	Conditioning	Saline		Nicotine
	Treatment	Saline	Imipramine	Saline	Imipramine
TAC	Brain	415.30 ± 11.00	420.10 ± 6.68	405.90 ± 16.54	407.70 ± 11.33
	Cortex	408.60 ± 7.89	409.80 ± 10.95	401.00 ± 5.398	400.30 ± 7.08
	Hippocampus	404.00 ± 6,61	407.20 ± 10.88	391.20 ± 14.58	397.20 ± 12.78
	Cerebellum	421.70 ± 9.37	418.00 ± 14.39	400.00 ± 7.42**	404.60 ± 12.10
GPx	Brain	124.30 ± 8.08	121.70 ± 6.82	96.80 ± 9.01***	108.49 ± 12.33#
	Cortex	125.20 ± 6.59	123.50 ± 8.11	112.90 ± 9.58*	115.80 ± 4.30
	Hippocampus	122.90 ± 6.69	139.20 ± 16.87*	114.40 ± 6.48	118.60 ± 6.48##
	Cerebellum	129.70 ± 4.94	144.00 ± 9.33***	119.70 ± 6.19*	121.50 ± 4.83###
SOD	Brain	5.18 ± 0.25	5.08 ± 0.15	4.85 ± 0.20*	4.80 ± 0.21**
	Cortex	9.87 ± 0.35	10.26 ± 0.79	8.76 ± 0.74**	9.15 ± 0.43##
	Hippocampus	19.86 ± 3.54	21.79 ± 1.43	17.76 ± 2.32	18.83 ± 1.59
	Cerebellum	8.08 ± 0.54	8.11 ± 0.28	7.49 ± 0.40*	7.61 ± 0.28
MDA	Brain	27.68 ± 1.59	28.77 ± 1.59	34.52 ± 0.84***	34.97 ± 1.77###
	Cortex	38.61 ± 2.21	34.86 ± 7.26	70.97 ± 4.52***	68.12 ± 3.73###
	Hippocampus	33.75 ± 1.56	30.74 ± 1.96	38.76 ± 1.60*	37.67 ± 5.12###
	Cerebellum	23.22 ± 1.38	21.27 ± 1.76	31.96 ± 1.19***	28.82 ± 2.75###, ^

Rats were subjected to the CUMS procedure for 21 days. Data represent means ± SEM, n = 10 rats per group

*P < 0.05, **P < 0.01, ***P < 0.001 vs. stressed saline-treated, saline-conditioned rats; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. stressed imipramine-treated, saline-conditioned rats; ^P < 0.05, ^^P < 0.01, ^^^P < 0.001 vs. stressed saline-treated, nicotine-conditioned rats (Tukey’s test)