Table 3.

Dissociation rate constants for [³H]5-CT, [³H]SB-269970, and [³H]mesulergine at the 5-HT₇ receptor expressed in HEK293 cells, in the absence and presence of 500 μM of zinc ions

Zn2+ [μM]	Dissociation rate	[3H]5-CT	[3H]SB-269970	[3H]mesulergine
0	koff [min−1]	0.070 ± 0.008	0.075 ± 0.008	0.059 ± 0.035
500	koffobs [min−1]	0.092* ± 0.005	0.068 ± 0.003	0.100* ± 0.007

*p < 0.05