Table 2.

FAMMM Diagnostic criteria for Familial Atypical Multiple Mole Melanoma syndrome [29]

1. Malignant melanoma in one or more first- or second-degree relatives

2. High total body nevi count (often >50) including some of which are clinically atypical (asymmetric, raised, color variegation present, of variable sizes)

3. Nevi with certain histologic features on microscopy*

*architectural disorder with asymmetry, subepidermal fibroplasia, and lentiginous melanocytic hyperplasia with spindle or epithelioid melanocytes; variable dermal lymphocyte infiltration and the “shouldering" phenomenon.

All three criteria are needed to make a diagnosis