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. 2018 Mar 7;11:36. doi: 10.1186/s13045-018-0581-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Co-treatment with VS-5584 and ICG-001 showed superior anti-AML efficacy in vivo in mouse xenograft models. a Mice were treated with vehicle control, VS-5584 5 mg/kg/day, ICG-001 50 mg/kg/day, or combination of two drugs respectively. Survival analysis showed that co-treatment with VS-5584 and ICG-001 significantly prolonged mice life than either of single treatment (p < 0.001). b Analysis of human CD45-positive cells in bone marrow samples harvested from mice at the endpoint of survival analysis by FACS method. Average of bone marrow chimerism was calculated as the average of 7 mice in each group ± SD (two-way ANOVA p = 0.0075)