Fig. 3.
The phagosomal pathway was enriched in Smokers vs Never-smokers in the joint gender model (p = 1.4 × 10−6, FDR = 2.7 × 10−5). Proteins with significantly increased levels are highlighted in red, and decreased levels in dark blue. (FcγR, P08637, Low affinity immunoglobulin γ Fc region receptor III-A; CR3, P11215/P05107, CD11b/CD18; αMβ2, P11215/P05107, CD11b/CD18; Collectins, Q8IWL1, Pulmonary surfactant-associated protein A2; SRA1, P21757, Macrophage scavenger receptor types I and II; MARCO, Q9UEW3, Macrophage receptor MARCO; TAP1, Q03518, Antigen peptide transporter 1; TAP2, Q03519, Antigen peptide transporter 2; F-actin, P60709, β-actin; Stx13, Q86Y82, Syntaxin-12; TfR, P02786, Transferrin receptor protein 1; LAMP, P13473, lysosome-associated membrane glycoprotein 2; Cathepsin S: P25774, Cathepsin S; Cathepsin L1: P07711, Cathepsin L1; vATPase: P38606, P21281, P61421, P21283, Q9Y5K8, P36543, O75348, Q9UI12, V-ATPase subunit A, B2, d1, C1, D, E1, G1, H, respectively; gp91, P04839, Cytochrome b-245 heavy chain; p40phox, Q15080, Neutrophil cytosol factor 4. Protein details are listed in Additional file 1: Table S5)