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. 2018 Mar 7;18:264. doi: 10.1186/s12885-018-4050-1

Table 5.

Intermolecular interactions between the VEGFR-2 inhibitors

Name of the compound Hydrogen bonds < 3 Å van der Waals interactions π-π
Residue atom Ligand atom Bond length
Reference Cys919:HN
Asp1046:NH
Asp1046: O
N7
O26
H62
2.2
2.0
2.0
Val848, Lys868, Glu885, Ile892, asn900, Leu901, Lys920, Phe921, Gly922, Asn923, Leu1019, leu1044, His1026 Phe1047 Leu840, Ala866, Ala866, Val898, Leu889, Leu1035
Hit Glu885:OE2
Cys919: O
Asp1046:HN
H36
H35
N5
1.88
2.9
2.3
Ala866, Glu850, Ile888, Ile892, Val898, Val914, Lys920, Asn923, Gly922, Leu1019, His1026, Ile1044, Phe1047 Leu840, Val848, Leu889, Lys868, Phe918, Leu1035