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. 2018 Mar 7;8:19. doi: 10.1186/s13578-018-0216-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effect of RSV on activating Wnt/β-catenin signaling in osteogenic differentiation in vivo. a ALP activity in calvaria of mouse PIO model pretreated with RSV (10 mg/kg/day) with or without ICG-001 (10 μL). b The mRNA expression levels of β-catenin in calvaria of mouse PIO model pretreated with RSV (10 mg/kg/day) with or without ICG-001 (10 μL). c The mRNA and protein expression levels of Runx2, Osterix and OCN in calvaria of mouse PIO model pretreated with RSV (10 mg/kg/day) with or without ICG-001 (10 μL). *P < 0.05 compared with sham group. ^&P < 0.05 compared with vehicle group. ^#P < 0.05 compared with RSV group