Fig. 3.

Receiver operating characteristic curve for p53 genotype prediction in the training and validation sets. (A) In the training set, the area under the curve (AUC) was 89.6%. The optimal cutoff value (0.138), determined as the point when the sensitivity plus specificity was maximal, exhibited a sensitivity, specificity, and accuracy of 80.3%, 84.6%, and 80.0%, respectively (red dot). (B) The AUC was 76.3% in the validation set. At the optimal cutoff value (0.181), the sensitivity, specificity, and accuracy were 62.2%, 85.1%, and 70.7%, respectively (red dot).