Fig. 3.

Comparison of XDP versus control tractography for striosome-weighted connectivity with the putamen (posthoc comparisons). Total termination tractography counts are shown for (A) Anterior Insula, (B), Anterior/subcallosal Cingulate, and (C) Orbitofrontal Cortex connectivity with the left (LH) and right (RH) putamen. Images (from fslview) to the left of graphs show representative sections through averaged healthy control tractography maps used in posthoc tractography analyses, superimposed on the MNI152_T1_1mm template. Left and right hemisphere tractography are depicted together in the images, but were evaluated separately for statistics. Note that these images are intended (and thresholded) to be qualitative only, and are included simply to illustrate the territory covered most prominently by each of the measures; they do not convey information about magnitude or spatial extent. *significant at p < 0.005; ^†trend toward significance (within an order of magnitude of the significance p threshold). (D) Relationship between left insula → putamen connectivity and mouth scores on the Burke Fahn Marsden (BFM) scale. (E) Absence of inverse relationship between sensorimotor → putamen and insula → putamen connectivity. XDP: X-linked dystonia-parkinsonism.